Topical formulations

ERCO Pharma’s stratum corneum model enables us to understand how components in topical formulations interacts with the barrier structure of the human skin. Using high performance molecular dynamics simulations we can help you optimize your topical formulation in order to maximize the partitioning of your drug molecule from the vehicle into the human skin.

Permeation enhancers inside ERCO’s stratum corneum model. a) No permeation enhancer (water associated with head groups shown), b) Azone, c) DMSO, d) Oleic acid, e) Stearic acid, f) Water as a permeation enhancer. (From Lundborg et al. Predicting drug permeability through skin using molecular dynamics simulation. J. Control. Release, 283 (2018))

Permeation enhancement

From our free energy calculations we can predict the permeation of solutes across the stratum corneum in the prescence of zero, one or more permeation enhancers. Using this data we can aid you in the development of your topical formulation in order to maximize the delivery of your active compound through the stratum corneum.