Enabling transdermal delivery by computer simulation


Start getting an increased understanding from your experiments

Using ERCO Pharma’s computational model we can obtain more information from your existing experimental data. A resolution down to atomic coordinates enables our model to explain how an API interacts with the skin barrier, which is critical for the development of improved transdermal delivery.


We can improve your topical formulations

ERCO Pharma’s technologies make it possible to study how modifications of your topical formulation changes the partitioning of the API and associated permeation enhancers into the skin barrier. This, combined with permeation simulations, allows us to guide you through the process of choosing the optimal permeation enhancers for maximized transdermal transport.



Our offering is built on four strong pillars

As all scientific challenges have their own unique hurdles, we are very adaptive in our offerings to deliver the best tailored solution to your problem.

Skin permeation

1

Using ERCO Pharma’s skin model we can obtain predicted permeation-rates of multiple solutes across the stratum corneum.

Topical formulations

2

Our skin model can help you optimize your topical formulation to maximize the permeability of your drug molecule through the skin barrier.

Computational work

3

We can provide computational expertise, contract calculation work, and we have the ability to work with passive transport over a multitude of biological membranes.

Product development

4

We use our molecular modeling approach in internal development projects, and depending on your specific needs we can enhance your workflows as well.


What are you looking to achieve?

I represent a

Pharmaceutical company

and want to understand how my drug formulation works, and how it can be improved.

I work for a

CRO company

and want new tools to help my pharmaceutical customers with transdermal drug projects.

I am from a

Cosmetics company

that wants to have a better scientific understanding of our products.


Our novel technology is based on

2

nobel prizes

Technologies awarded two Nobel prizes

By combining molecular dynamics simulations (a technology awarded the Nobel Prize in Chemistry in 2013) with human in vivo data obtained with cryo-electron microscopy (a technology awarded the Nobel Prize in Chemistry in 2017) we have elucidated the basic molecular structure and function of the human skin’s permeability barrier.

20

years of research

Over twenty years of research at Karolinska Institutet

Co-founded by one of the world leaders in skin barrier structure determination, ERCO Pharma’s technology is based on 20 years of research at Karolinska Institutet in Stockholm, Sweden.

Featured publications

  • Predicting drug permeability through skin using molecular dynamics simulation

  • Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation

  • Molecular reorganization during formation of the human skin barrier studied in situ

Let us help you improve your formulations

Let us present our scientific technology and show you how ERCO Pharma can help your business.